ORNIMIX Clone B1+H120

Indication: For active immunization of fowl against Newcastle avian disease and infectious bronchitis of Massachusetts type. For prevention of infection and mortality caused by Newcastle disease virus and by infectious bronchitis virus. Onset of immunity: The immunity against Newcastle disease and infectious bronchitis starts not later than 14 and 7 days after primovaccination, respectively, and maternal antibodies have no negative influence on the efficacy of vaccination. Time of immunity duration: The immunity lasts for 6 weeks after spray and oculonasal primovaccination and 4 weeks after per oral primovaccination. After revaccination, the immunity persists for 6 weeks as a minimum. The level of immunity against Newcastle disease can be evaluated after revaccination on the basis of serological examination. Contraindication: Only healthy animals should be vaccinated. Do not use in animals that are showing signs of disease Adverse reactions: Post-vaccination reactions may occur in particular after unsuitable vaccine application by spraying, because fine micro-droplets (aerosol mist) cause inhalation of the vaccination virus into the lower air passages and respiratory disease as its consequence. Therapeutic form: Domestic fowl – chickens from the age of one day. Dosage for each species, rote(s) and method of administration: Individual oculonasal application: The lyophilized vaccine is dissolved in a sterile solvent (e.g. water for injections). The vaccine is applied by a common eye-dropper onto the conjunctiva mucosa or nostril of individual birds; it is necessary to provide breath suction of the droplet by the animal. Mass spray application: Distilled water or cool purified water free from chlorine and iron residues is used for vaccine dissolving. The device, specified exclusively for this purpose and generating droplets (diameter of 30 to 100 ?m) is used for vaccination. For one day chickens 1000 doses will be dissolved in the 200-250 volume; the sprayer nozzle has to be set to generation of a “coarse spray” = small droplets falling as a fine rain. For older poultry 1000 doses are dissolved in one litre of water and the sprayer nozzle is set to generation of fine droplets. The vaccination solution is sprayed uniformly at the distance of 30 to 50 cm above the adequate number of animals under soft lighting. Mass application into potable water: It is recommended to vaccinate the chickens from the 4th day after hatching, when reliable intake of the vaccination dose in potable water can be assumed. The vaccine is administered in the morning, when the poultry is thirsty enough. The vaccine is administered (depending on age) dissolved in such potable water quantity which will be consumed within 2 hours. Re-vaccination is carried out every six weeks after the first oculonasal or spray administration and in 4 weeks after the first peroral vaccination. Further vaccinations are carried out every six weeks. In the regions with endemic occurrence of the Newc